Pablo Blinder lab

Osher Y, Rom A, Perel R, Lahini Y, Blinder P, Shein-Idelson P* Sequentially activated discrete modules appear as traveling waves in neuronal measurements with limited spatiotemporal sampling. eLIFE, 12:RP92254 (March 2024). 

 

Dubiner S, Kashi A, Drabkin A, Blinder P, Levin E Patterns of fatty acid usage in two nocturnal insectivores: the Mediterranean house gecko (Hemidactylus turcicus) and the Etruscan pygmy shrew (Suncus etruscus) . J. Exp. Biol., 226 (19): jeb245963 (October 2023). 

 

Benbenishty A, Peled-Hajaj S, Krishnaswamy VR, Har-Gil H, Havusha-Laufer S, Ruggiero A, Slutsky I, Blinder P*, Sagi I* Longitudinal in vivo imaging of perineuronal nets. Neurophotonics, Vol. 9, Issue 3, 031920 (September 2022). 

 

Blinder P. The pledge for a new era of biology-applied network theory: Comment on “Networks behind the morphology and structural design of living systems” by Gosak et al. Physics of Life Reviews
Volume 43, December 2022, Pages 26-28  

 

Har-Gil H, Golgher L, Kain D and Blinder P. Versatile software and hardware combo enabling photon counting acquisition and real-time display for multiplexing, 2D and continuous 3D two-photon imaging applications. Neurophotonics, Vol. 9, Issue 3, 031920 (September 2022). 

 

Shapira R, Gdalyahu A, Gottfried I, Sasson E, Hadanny A, Efrati S, Blinder P, Ashery U. Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients. Aging (Albany NY). 2021 Sep 9;13(17):20935-20961. doi: 10.18632/aging.203485. 

 

Goldshmit Y, Perelroizen R, Yakovchuk A, Banyas E, Mayo L, David S, Benbenishty A, Blinder P, Shalom M, Ruban A. Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo. Sci Rep. 2021 Jul 19;11(1):14644. doi: 10.1038/s41598-021-94183-8.

 

Cohen D, Mashiach R, Houben L, Galisova A, Addadi Y, Kain D, Lubart A, Blinder P, Allouche-Arnon H, Bar-Shir A. Glyconanofluorides as Immunotracers with a Tunable Core Composition for Sensitive Hotspot Magnetic Resonance Imaging of Inflammatory Activity. ACS Nano. 2021 Apr 27;15(4):7563-7574. doi: 10.1021/acsnano.1c01040. Epub 2021 Apr 19. 

 

Jung-Seok Kim, Masha Kolesnikov, Shany Peled-Hajaj, Isabelle Scheyltjens, Yuan Xia, Sebastien Trzebanski, Zhana Haimon, Anat Shemer, Alisa Lubart, Hanna Van Hove, Louise Chappell-Maor, Sigalit Boura-Halfon, Kiavash Movahedi, Pablo Blinder and Steffen Jung.  Dissecting functional contributions of microglia and CNS border-associated macrophages using a novel binary transgenic approach. Immunity. 2021 Jan 12;54(1):176-190.e7. doi: 10.1016/j.immuni.2020.11.007.  

 

Alisa Lubart*, Amit Benbenishty*, Hagai Har-Gil, Hadas Laufer, Amos Gdalyahy, Yaniv Assaf and Pablo Blinder. Single Cortical Microinfarcts Lead to Widespread Microglia/Macrophage Migration Along the White Matter . Cerebral Cortex. (2020).  

 

Humberto Mestre, Ting Du,Amanda M. Sweeney, Guojun Liu, Andrew J. Samson,Weiguo Peng, Kristian Nygaard Mortensen, Frederik Filip Stæger, Peter A.R. Bork, Logan Bashford, Edna R. Toro, Jeffrey Tithof, Douglas H. Kelley, John H. Thomas, Poul G. Hjorth, Erik A. Martens, Rupal I. Mehta, Orestes Solis, Pablo Blinder, David Kleinfeld, Hajime Hirase, Yuki Mori and Maiken Nedergaard. Cerebrospinal fluid influx drives acute ischemic tissue swelling. Science. 367 (6483) (2020).

 

Benbenishty A, Gadrich M, Cottarelli A, Lubart A, Kain D, Amer M, Shaashua L, Glasner A, Erez N, Agalliu D, Mayo L, Ben-Eliyahu S, Blinder P. Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation.. PLoS Biology. (2019).

Shortly after its publication, on May 3rd, 2019, Nature Reviews Cancer highlighted the work with a brief news article: “Better safe than sorry: a potential prophylactic treatment for brain metastasis”.

 

Amy F., Doyeux Vincent, Berg Maxime, Peyrounette Myriam, Haft-Javaherian Mohammad, Larue Anne-Edith, Slater John H., Lauwers Frédéric, Blinder Pablo, Tsai Philbert, Kleinfeld David, Schaffer Chris B., Nishimura Nozomi, Davit Yohan, Lorthois Sylvie .Brain Capillary Networks Across Species: A few Simple Organizational Requirements Are Sufficient to Reproduce Both Structure and Function.  Frontiers in Physiology. (2019).

 

Huan Wang, Yi‐Xuan Yin, Dong‐Mei Gong, Ling‐Juan Hong, Gang Wu, Quan Jiang, Cheng‐Kun Wang, Pablo Blinder, Sen Long, Feng Han and Ying‐Mei Lu. .Cathepsin B inhibition ameliorates leukocyte‐endothelial adhesion in the BTBR mouse model of autism.  CNS Neurosci Ther. (2018).

 

Hagai Har-Gil*, Lior Golgher*, Shai Israel, David Kain, Ori Cheshnovsky, Moshe Parnas, Pablo Blinder. PySight: plug and play photon counting for fast continuous volumetric intravital microscopy. *equal contribution. Optica (2018) 5 (9), 1104-1112.

This paper has been selected by Optica Editorial Board for press release titled: “Enhanced 3D Imaging Poised to Advance Treatments for Brain Diseases” and it has been featured in several important news outlets: EurekaAlert!, Phys.Org, Businesswire, Radiology Business (“Microscope add-on could be a game-changer for 2D, 3D brain imaging“), Drug Target Review (“Enhanced 3D neuron imaging could diagnose brain disease“), Photonics Media (“Microscopy Add-On Enhances Neuronal Image Resolution Under Dim Conditions“), ITWeb (“Open source contributes to medical innovation“), MedGadget (“Looking Deep Into Living Brain Using Photon Counter on Laser Scanning Microscope“) and NovusLight (“Photon Counting Solution Advances 3D Imaging of Living Brain“).

 

Lia Papadopoulos, Pablo Blinder, Henrik Ronellenfitsch, Florian Klimm, Eleni Katifori, David Kleinfeld, Danielle S Bassett. Comparing two classes of biological distribution systems using network analysis.  PLoS Computational Biology (2018) 14 (9), e1006428.

 

Yamit Cohen-Tayar, Hadar Cohen, Yulia Mitiagin, Zohar Abravanel, Carmit Levy, Masha Idelson, Benjamin Reubinoff, Shalev Itzkovitz, Shaul Raviv, Klaus H Kaestner, Pablo Blinder, Ran Elkon, Ruth Ashery-Padan. Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development.  Development (2018) 145 (15), dev163691.

 

MD Adams, AT Winder, P Blinder, PJ Drew. The pial vasculature of the mouse develops according to a sensory-independent programresponses.  Scientific Reports (2018) 8 (1), 9860.

 

Benbenishty Amit, Segev-Amzaleg Niva, Shaashua Lee, Melamed Rivka, Ben-Eliyahu Shamgar, Blinder Pablo. Maintaining unperturbed cerebral blood flow is key in the study of brain metastasis and its interactions with stress and inflammatory responses.  Brain Behav Immun (2017) Epub 2017 Feb 20.

 

Iram T, Trudler D, Kain D, Kanner S, Galron R, Vassar R, Barzilai A, Blinder P, Fishelson Z, Frenkel D. Astrocytes from old Alzheimer’s disease mice are impaired in Aβ uptake and in neuroprotection. Neurobiol Dis. (2016) 96:84-94

 

[av_font_icon color=”#2997AB” icon=”56″ size=”35px”] A. Y. Shih*, C. Rühlmann*, P. Blinder, A. Devor, P. J. Drew. B. Friedman, P. M. Knutsen, P. D. Lyden, C. Mateo, L. Mellander N. Nishimura, C. B. Schaffer, P. S. Tsai and D. Kleinfeld. Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation(2015) 22:204-218.

 

P Blinder*, P. S. Tsai*, J. K. Kaufhold, P. M. Knudsen, H. Suhl and D. Kleinfeld. The cortical angiome: A 3-D interconnected vascular network with noncolumnar patterns of blood flow.  Nature Neuroscience (2013) 16:889-897. *Equal contribution.

 A 2-star F1000Prime selection.    The Research Brief “Mouse brain circulatory system knows no bound?” appeared in the Alzheimer Research Forum.    Articles based on the UCSD press release “3-D map of blood vessels in cerebral cortex holds surprises” appeared in Africa-News, Association Alzheimer-Riese (Italy), Bio-Medicine, EurekAlert, Health Medicine Network, Journaux-Francais, MedicalPress (Spain), MyScience, News-Medical (France; Germany; Italy; Korea Poland; Russia; Spain), ScienceDaily, and ZeeNews. The article “In Natural Networks, Strength in Loops” by Emily Singer appeared in the Quanta Magazine.

 

A. Y. Shih, P. Blinder, P. S. Tsai, B. Friedman, G. Stanley, P. D. Lyden and D. Kleinfeld. The smallest stroke : occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nature Neuroscience (2013), 16(1):55:63.

 

J. P. Kaufhold, P. S. Tsai, P. Blinder and D Kleinfeld. Vectorization of optically sectioned brain microvasculature: learning aids completion of vascular graphs by connecting gaps and deleting open- ended segments. Medical image analysis (2012), 16(6):124158.

D. Kleinfeld, A. Bharioke, P. Blinder, D. D. Bock, K. L. Briggman, D. B. Chklovskii, W. Denk, M. Helmstaedter, J. P. Kaufhold, W.-C. a. Lee, H. S. Meyer, K. D. Micheva, M. Oberlaender, S. Prohaska, R. C. Reid, S. J. Smith, S. Takemura, P. S. Tsai, and B. Sakmann. Large- Scale Automated Histology in the Pursuit of Connectomes. Journal of Neuroscience (2011), 31(45):1612516138

 

D. Kleinfeld, P. Blinder, P. J. Drew, J. D. Driscoll, A. Muller, P. S. Tsai and A. Y. Shih. A guide to delineate the logic of neurovascular signaling in the brain. Frontiers in Neuroenergetics (2011): Special Issue on Neurovascular Imaging 3 (1).

 

P. J. Drew, A. Y. Shih, P. S. Tsai, P. Knutsen, D. Davalos, P. Blinder, K. Akassoglou and D. Kleinfeld. Large-scale chronic imaging and optical manipulation of cortical cells through a polished and reinforced thinned-skull. Nature Methods (2010), 7(12):981984.

 

P. Blinder*, A. Y. Shih*, C. A. Rafie and D. Kleinfeld. Topological basis for the robust distribution of blood to rodent neocortex. PNAS (2010). Volume 107, Issue 28, 12670-12675. *Equal contribution.

 

Ehud Cohen, Johan F. Paulsson, Pablo Blinder, Tal Burstyn-Cohen, Deguo Du, Gabriela Es- tepa, Anthony Adame, Hang M. Pham, Martin Holzenberger, Jeffery W. Kelly, Eliezer Masliah and Andrew Dillin. Reduced IGF-1 Signaling Delays Age-associated Proteotoxicity in Mice. Cell (2009) Volume 139, Issue 6, 1157-1169, 11. doi:10.1016/j.cell.2009.11.014

 

Philbert. S. Tsai, John. P. Kaufhold, Pablo. Blinder, Beth. Friedman, Patrick. J. Drew, Harvey. J. Karten, Patrick. D. Lyden and David. Kleinfeld. Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci. 2009 Nov 18;29(46):14553-70.

 

Patrick J. Drew, Pablo Blinder, Gert Cauwenberghs, Andy Y. Shih and David Kleinfeld. Rapid determination of particle velocity from space-time images using the Radon transform. Journal of Computational Neuroscience 2009.

 

Tsai PS, Blinder P, Migliori BJ, Neev J, Jin Y, Squier JA, Kleinfeld D. Plasma-mediated ab- lation: an optical tool for sub micrometer surgery on neuronal and vascular systems. Cur- rent Opinion in Biotechnology (2009) Vol 20, Issue 1, 90-97. PubMed PMID: 19269159.

 

Blinder P, Cove J, Foox M, Baranes D. Convergence among non-sister dendritic branches: an activity-controlled mean to strengthen network connectivity. PLoS ONE. 2008;3(11):e3782. Epub 2008 Nov 21. PubMed PMID: 19023423; PubMed Central PMCID: PMC2582457.

 

Cove J, Blinder P, Baranes D. Contacts among non-sister dendritic branches at bifurcations shape neighboring dendrites and pattern their synaptic inputs. Brain Res. 2009 Jan 28;1251:30

 

Peretz H, Blinder P, Baranes D, Vago R. Aragonite crystalline matrix as an instructive microen- vironment for neural development. J Tissue Eng Regen Med. 2008 Dec;2(8):463-71. PubMed PMID: 18924122.

 

Baranes D, Cove J, Blinder P, Shany B, Peretz H, Vago R. Interconnected network of ganglion- like neural cell spheres formed on hydrozoan skeleton. Tissue Eng. 2007 Mar;13(3):473-82. PubMed PMID: 17518598.

 

Shany B, Peretz H, Blinder P, Lichtenfeld Y, Jeger R, Vago R, Baranes D. Aragonite crys- talline biomatrices support astrocytic tissue formation.